Carlos Cepeda, Ph.D

Research

Understanding neuronal and synaptic mechanisms underlying the pathophysiology of Huntington’s disease and epilepsy.

Research

Understanding neuronal and synaptic mechanisms underlying the pathophysiology of Huntington’s disease and epilepsy.

Appointments

Professor of Psychiatry & Biobehavioral Sciences

Appointments

Professor of Psychiatry & Biobehavioral Sciences

Dr. Cepeda’s research focuses on understanding the mechanisms underlying neuronal dysfunction in the basal ganglia and cerebral cortex in neurological disorders including Huntington’s disease in animal models and epilepsy in children with malformations of cortical development.

This work combines electrophysiological and morphological techniques in brain slices.

More recently, his research uses advanced methods to visualize live neurons in freely moving animals with the aid of miniscopes and calcium reporters.

Publications

Li Wenyuan , Ovchinnikov Igor V., Chen Honglin , Wang Zhe , Lee Albert , Lee Houchul , Cepeda Carlos , Schwartz Robert N., Meier Karlheinz , Wang Kang L. A Basic Phase Diagram of Neuronal Dynamics. Neural Comput 30 (2018) 2418-2438
Barry Joshua , Akopian Garnik , Cepeda Carlos , Levine Michael S. Striatal Direct and Indirect Pathway Output Structures Are Differentially Altered in Mouse Models of Huntington's Disease. J. Neurosci. 38 (2018) 4678-4694
Lee Kwang , Holley Sandra M., Shobe Justin L., Chong Natalie C., Cepeda Carlos , Levine Michael S., Masmanidis Sotiris C. Parvalbumin Interneurons Modulate Striatal Output and Enhance Performance during Associative Learning. Neuron 99 (2018) 239
Reidling Jack C., Relaño-Ginés Aroa , Holley Sandra M., Ochaba Joseph , Moore Cindy , Fury Brian , Lau Alice , Tran Andrew H., Yeung Sylvia , Salamati Delaram , Zhu Chunni , Hatami Asa , Cepeda... Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice. Stem Cell Reports 10 (2018) 58-72
Solís-Maldonado Macarena , Miró María Paz, Acuña Aníbal I., Covarrubias-Pinto Adriana , Loaiza Anitsi , Mayorga Gonzalo , Beltrán Felipe A., Cepeda Carlos , Levine Michael S., Concha Ilona I., Bátiz... Altered lactate metabolism in Huntington's disease is dependent on GLUT3 expression. CNS Neurosci Ther 24 (2018) 343-352

Pages