Gary W. Mathern, M.D.

Research

Anatomic changes in human brain tissue removed to control epilepsy

Research

Anatomic changes in human brain tissue removed to control epilepsy

Appointments

Director, Epilepsy Surgery

Pediatric Epilepsy Program

Professor, Neurosurgery

Professor in Residence, Surgery

Member, Brain Research Institute

Neuroscience GPB Home Area

Pediatric Neuro-oncology and Neural Tumors Center

Appointments

Director, Epilepsy Surgery

Pediatric Epilepsy Program

Professor, Neurosurgery

Professor in Residence, Surgery

Member, Brain Research Institute

Neuroscience GPB Home Area

Pediatric Neuro-oncology and Neural Tumors Center

The Mathern laboratory is involved in the study of children who undergo surgery for intractable epilepsy. These children are at significant risk for intellectual and developmental disabilities as a consequence of both their seizures and the underlying substrate responsible for the epilepsy. In order to control the seizures (and hopefully reduce seizure- induced intellectual and developmental disabilities), large areas of brain are removed. Depending on the severity of seizures, this may include a hemispherectomy.

In collaboration with Levine’s laboratory, in vitro electrophysiological experiments and histological studies from surgically resected brain tissue are performed in parallel.

Together, the physiological and anatomical techniques may lead to new interventions/treatments for infantile epilepsy and thus potentially reduce the consequences for intellectual disabilities in these children.

Publications

de Bode Stella , Smets Lieselotte , Mathern Gary W., Dubinsky Stanley Complex syntax in the isolated right hemisphere: Receptive grammatical abilities after cerebral hemispherectomy. Epilepsy Behav 51 (2015) 33-9
Mathern Gary W., Beninsig Laurie , Nehlig Astrid Should consciousness describe seizures and what terms should be applied? Epilepsia's survey results. Epilepsia 56 (2015) 340-3
Baca Christine B., Pieters Huibrie C., Iwaki Tomoko J., Mathern Gary W., Vickrey Barbara G. "A journey around the world": Parent narratives of the journey to pediatric resective epilepsy surgery and beyond. Epilepsia 56 (2015) 822-32
Diamond Matthew , Mathern Gary , Nehlig Astrid , Sperling Michael Interview with Matthew Diamond, 2014 Epilepsia prize winner. Epilepsia 56 (2015) 987-8
Jehi Lara , Mathern Gary W. Who's responsible to refer for epilepsy surgery? We all are! Neurology 84 (2015) 112-3

Pages